Sri Sathya Sai Institute of Higher Medical Sciences – Congenital Heart Disease
Factors predicting the progress of mitral valve disease in surgically treated adults with ostium primum atrial septal defects.
Vijay Agarwal, MCh, FRCSa, Suneil Kumar Aggarwal, MRCPb,*, Choudary D. Voleti, MD, FACSa
- Department of Cardiothoracic and Vascular Surgery, Sri Sathya Sai Institute of Higher Medical Sciences, Prashantigram, India
- Department of Cardiology, Sri Sathya Sai Institute of Higher Medical Sciences, Prashantigram, India
Received for publication March 6, 2008; revisions received June 23, 2008; accepted for publication August 28, 2008.
Address for reprints: Suneil K. Aggarwal, MRCP, Department of Cardiology, Sri Sathya Sai Institute of Higher Medical Sciences, Prashantigram, AP 515134, India.
Objective: This study was undertaken to analyze the clinical profile, associated features, and surgical treatments of adults operated on for ostium primum atrial septal defects, particularly factors influencing progression of mitral valve disease.
Methods: We retrospectively studied all patients aged 18 years and older operated on at our institution with reference to patient clinical features, investigation findings, surgical records, and outpatient follow-up data.
Results: Fifty-one patients, 29 female and 22 male, underwent operation at a mean age of 27.3 years (SD 6.9). Of these, 80% were in New York Heart Association functional class I or II, with a most frequent presenting symptom of dyspnea. On echocardiography, 88% had cleft mitral valve, 35% had moderate mitral regurgitation, and 4% had severe mitral regurgitation. According to echocardiography and available cardiac catheterization data, 27% had moderate pulmonary arterial hypertension and 8% had severe. In-hospital mortality was 1.9%. At mean follow-up of 36 months, 94% of patients were in functional class I. Mitral regurgitation was moderate in 21% and severe in 8%, with 1 patient undergoing mitral valve replacement. Factors associated with increased risk of moderate or severe mitral regurgitation on follow-up were preoperative moderate or severe pulmonary arterial hypertension (P = .008) and female sex (P = .009).
Conclusion: Surgical correction of ostium primum atrial septal defects in adults can be undertaken successfully with low mortality and excellent symptomatic results. Regular follow-up is required to assess progression of mitral regurgitation, which is more likely in women and those with preoperative pulmonary arterial hypertension.
Abbreviations and Acronyms:
- MR = mitral regurgitation
- NYHA = New York Heart Association
- OPASD = ostium primum atrial septal defect
- PAH = pulmonary arterial hypertension
- RVSP = right ventricular systolic pressure
- TR = tricuspid regurgitation
Filed under: Choudary D Voleti, Congenital Heart Disease, Mitral Valve, Ostium Primum Atrial Septal Defect, Prashantigram, Sri Sathya Sai Institute of Higher Medical Sciences, Suneil Kumar Aggarwal, The American Association For Thoracic Surgery, The Journal Of Thoracic And Cardiovascular Surgery, Vijay Agarwal | Tagged: Clinical, Disease, Health, Heart, Hospital, India, Inpatient, Medical, Medicine, Outpatient, Research, sathya sai baba, Science, Surgery | Comments Off